Lemon Grass Tea Enhanced Memory Function and Attenuated Scopolamine-lnduced Amnesia in Mice Via Inhibition of Oxidative Stress and Acetylcholinesterase Activity

摘要

The aqueous leaf extract of Cymbopogon citratus (CYC) was evaluated for memory functions on scopolamine (SCO)-induced amnesia in mice. Male mice received CYC (25, 50, or 100 mg kg-') or saline (10 mL kg-1) orally for 7 consecutive days. In the interaction studies, the mice were given CYC (25, 50, or 100 mg kg-1, p.o) 30 min before SCO (3 mg kg"1, i.p) for 7 consecutive days. Thirty minutes after the last treatment in each case, memory function was evaluated using Y-maze and object recognition tests.The biomarkers of oxidative stress (malondialdehyde and glutathione) and acetyl-cholinesterase activity in the brain of SCO-treated mice were also determined. CYC increased memory performance and attenuated SCO-induced amnesia in mice. The extract also attenuated increased oxidative stress and acetyl-cholinesterase activity induced by SCO. Findings of this study suggested the potential use of the aqueous leaf extract of C. citratus as a phytother-apeutic agent for memory decline.