Stemming from its use in movement disorders, deep brain stimulation (DBS) has emerged as an experimental therapy for treatment-resistant cases of major depressive disorder, obsessive-compulsive disorder, and Tourette's syndrome. Early, positive results from case studies have led to controlled trials evaluating the use of DBS in each of these conditions. Results have been varied but suggest moderate benefit in many cases and remain encouraging. As the relative safety and potential efficacy of DBS has become more widely accepted, its use has expanded to include the treatment of other psychiatric disorders and symptoms including anorexia nervosa, substance use disorder, aggression, and Alzheimer's disease. Case studies using DBS for each of these have reported benefits.
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