Effect of Chloral Hydrate Anaesthesia on the Cerebral Metabolic Response to Apomorphine Administration

摘要

Using the quantitative 14C-2-deoxyglucose method to measure glucose utilisation in discrete areas of the brain, we have shown that chloral hydrate anaesthesia causes a marked depression of cerebral metabolism in all grey matter areas measured. Moreover, chloral hydrate anaesthesia can reduce, abolish or reverse the action of apomorphine upon glucose utilisation from that seen in conscious animals.