【Background】 Long-term immunosuppression is associated with an increased risk of cancer. Especially in pancreas transplantations, more intensive immunosuppression is used than in other organ transplantations because of strong immunogenicity. The aim of this studywas to analyze the incidence of de novo malignancies after pancreas transplantations in Japan. 【Methods】 Posttransplant patients with de novo malignancies were surveyed and characterized. 【Results】 Among 107 cases receiving a pancreas transplantation in Japan from 2001 to 2010, de novo malignancy developed in 9 cases; posttransplant lymphoproliferative disorder (PTLD) in 6, malignant brain tumor in 1, renal cell carcinoma in 1, and colon cancer in 1. 【Conclusions】 We clarified the incidence of de novo malignancies after pancreas transplantation in Japan.
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