Investigation of singlet oxygen reactivity towards propofol

摘要

The reaction between the anaesthetic agent 2,6-diisopropylphenol (propofol,PPF) and singlet oxygen (~1O_2) has been investigated in aqueous solution by means of HPLC,GC,absorption spectroscopy and laser flash photolysis with infrared luminescence detection.The rate constants for the physical and chemical quenching of ~1O_2 by PPF (kappa_(PPF)) are found to be 2.66X10~5 M~(-1) s~(-1) and approx3.2X10~6 M~(-1) s~(-1) in CD_3OD and D_2O-CD_3OD (75:25 v/v),respectively.The reaction of propofol with singlet oxygen produced by light irradiation of Rose Bengal leads essentially to two reaction products,2,6-diisopropyl-p-benzoquinone and 3,5,3',5'-tetraisopropyl-(4,4')-diphenoquinone that are unambiguously identified from comparison with authentic samples.