Hemodynamic and Metabolic Effects of Glucagon in Acute Hemorrhagic Pancreatitis

摘要

Dogs were randomly allocated to four groups: untreated normals; untreated pancreatitis; glucagon-treated normals, and glucagon-treated pancreatitis.Pancreatitis was induced by injection of an incubatedtrypsin-bile-blood mixture into the pancreatic duct. Glucagon-treated pancreatitis animals showed lower systemic blood pressure, decreased superior mesenteric arteryblood flow, and greater late reactive hypoglycemia as compared with pancreatitis controls. There were no differences in central venous or portal pressures, blood gases or in serum amylase.