Absolute bioavailability of terbutaline from a CR‐granulate in asthmatic children

摘要

AbstractThe study aimed at finding the absolute bioavailability of terbutaline of a newly developed CR‐granulate. Eight asthmatic children, aged 8–13 years, were given 3 mg of terbutaline as the CR‐granulate, concomitant with the intravenous administration of 0·100 mg of deuterium‐labelled terbutaline. The labelling of the intravenous dose made possible a separation, in the analytical step, of terbutaline originating from the intravenous and oral administration. Maximal plasma concentration, 8·7 (range: 4·9–15·2) nmoll−1, was reached after 4·7 (2·2–6·0) h. Absolute bioavailability was 10·8 (7·63–16·4) per cent. The parameter values were similar to those found after administration of terbutaline CR‐tablets to adults. The CR‐formulation is easily swallowed and can be dosed twice daily. Thus it should be a good alternative to elixir or plain tab