The Protective Effect of Vasopressin during Occlusion of the Portal Vein in Pigs

摘要

In experimental orthotopic liver transplantation in pigs portal vein occlusion results in increased capillary pressure in the splanchnic area, leading to rupture and leakage through the capillary walls and a possible irreversible disturbance of the portal perfusion. These harmful effects can be avoided by vasopressin which constricts the splanchnic arterioles. With this treatment portal pressure never exceeded 20 of arterial pressure during the 45-min portal occlusion compared to 80°/o in untreated animals. Vasopressin administration prior to clamping of the portal vein assures a firm and constant contraction of the splanchnic arterioles and prevents capillary damage