XY female mice express H‐Y antigen

摘要

AbstractKaryotypically XY individuals of the C57BL/6J‐YPOSmouse stock develop as females or hermaphrodites, but never as normal males. The aberrant sexual development results from the interaction of the C57BL/6J genetic background with the M. poschiavinus‐derived Y chromosome. XY females from this stock were assayed for H‐Y antigen. By the criteria of skin‐grafting, the cell‐mediated lympholysis test, and the popliteal lymph node assay, these XY females are antigenically indistinguishable from normal C57BL/6 males. Implications for the hypothesis that H‐Y antigen induces formation of the mammalian testis ar