Striking conservation of three extended HLA‐DR13 haplotypes in the Japanese population

摘要

Abstract:HLA class II DNA typing was conducted for 1335 unrelated Japanese individuals. The study on the linkage disequilibrium revealed a striking conservation of HLA DR13 haplotypes. Among these Japanese, 155 were typed for HLA‐DR13 serologically, and they were correspondent to three DRB1 alleles, DRB1*1301, 1302 and 1307 defined by using the polymerase‐chain reaction and sequence‐specific oligonucleotide probe (PCR‐SSOP) method. The two alleles, DRB1*1301 and 1307 were exclusively associated with each specific DRB3‐DQA1‐DQB1 combination which was DRB1*1301‐DRB3*0101‐DQA1*0103‐DQB1*0603, and DRB1*1307‐DRB3*0202‐DQA1*0501‐DQB1*0301, respectively. DRB1* 1302, the most common DR13 allele in Japanese, had two significant associations with DRB3*0301‐DQA1*0102‐DQB1*0604 (DRB1*1302A) and with DRB3*0301‐DQA1*0102‐DQB1*0605 (DRB1*1302B). In this study, no other DR13 class II combinations were found. Ony the DRB1*1302A halotype was associated with the DPB1*0401 allele while the DRB1*1302B haplotype was not. The complete conservation of these DR13 class II haplotypes was found to extend toward the HLA class I region. They were HLA A3‐B44‐DRB1*1301, A33‐B44‐DRB1*1302A and A33‐B17‐DRB1*1302B. Japanese could be characterized with these three extended haplotypes which were remakrably different from those in Caucasian, Bl