Functional and phenotypic properties of subpopulations of murine thymocytes.I. The bulk of peanut agglutinin‐positive Lyt‐1,2,3 thymocytes lacks precursors of cytotoxic T lymphocytes responsive to interleukin 2 (T cell growth factor)

摘要

AbstractThymocytes were separated according to their surface phenotype and tested for cytotoxic T lymphocyte (CTL) precursor function by stimulation with allogeneic or hapten‐coupled cells, with or without addition of T cell growth factor (interleukin 2). The data show that only a minor subpopulation of thymocytes agglutinated by peanut agglutinin, expressing relatively high amounts of H‐2K antigen, contained CTL precursors. The remaining population, approximately 80, could not be induced to generate CTL, even in the presence of interleuki