X-irradiation (600 R) of Lewis strain recipient rats had no effect on subsequent adoptive immunization with encephalitogen-sensitized lymph node cells. Adoptive immunization with irradiated (200–600 R) encephalitogen-sensitized lymph node cells resulted in clinical signs of experimental allergic encephalomyelitis (EAE), and a reduced number of histopathologic lesions. Irradiation of both recipients and sensitized donor cells resulted in clinical signs, but only mild lesions of EAE. Subsequent injection of ‘nonsensitized’ lymph node cells did not increase the severity of EAE in these animals. The results suggested that the production of clinical signs by radioresistant sensitized lymphoid cells was not dependent upon interaction with radiosensitive lymphoid cells. Radiosensitive cells, however, appeared to be important for optimal development of microscopic le
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