The myelosuppressive effect of recombinant interferon γ in short‐term and long‐term marrow cultures

摘要

SummaryThe effect of a highly purified human gamma IFN (r‐γ‐IFN) on the growth of haemopoietic progenitors was examined in soft agar assays and in long‐term bone marrow cultures. r‐γ‐IFN reduced colony formation by progenitor cells of the granulocyte/macrophage lineage (GM‐CFC). the eryth‐roid lineage (BFU‐E) and multipotent cells (GEMM‐CFC), and suppressed haemopoiesis in long‐term culture in a dose‐related fashion. At high doses (1000 units/ml) r‐γ‐IFN appeared to be toxic to the stro