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>Ontogenetic studies on tryptophan transport into plasma membrane vesicles derived from rat brain synaptosomes: Effect of thyroid hormones
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Ontogenetic studies on tryptophan transport into plasma membrane vesicles derived from rat brain synaptosomes: Effect of thyroid hormones
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机译:Ontogenetic studies on tryptophan transport into plasma membrane vesicles derived from rat brain synaptosomes: Effect of thyroid hormones
The uptake of tryptophan at various stages of development was examined in plasma membrane vesicles derived from rat brain. The total uptake has two components Na+-dependent and Na+-independent respectively. The Na+-dependent component of the transport system appears around the 5th postnatal day and increases with the age. TheKmvalue of the system does not vary during development. The Vmaxincreases five-fold between 14 and 35 day of postnatal life. Plasma membrane vesicles derived from T3-treated rats are able to accumulate nearly three-fold more tryptophan than nontreated rats. The results support the idea that thyroid hormones at the earlier stages of life, promote the establishment of neurotransmission in the developing nervous system.
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