首页>
外文期刊>Pesticide science
>Pharmacokinetics and in‐vivo Metabolism of Gamma‐Hexachlorocyclohexane in a Susceptible Strain of the Egyptian Cotton Leafworm,Spodoptera littoralis(Boisd.)
【24h】
Pharmacokinetics and in‐vivo Metabolism of Gamma‐Hexachlorocyclohexane in a Susceptible Strain of the Egyptian Cotton Leafworm,Spodoptera littoralis(Boisd.)
AbstractThe fate of gamma‐HCH (hexachlorocyclohexane) was studied in a susceptible strain of the Egyptian cotton leafworm,Spodoptera littoralis(Boisd.). A non‐lethal dose (0·2 μg larva−1) was topically applied to fourth‐instar larvae, and the pharmacokinetics of the insecticide were studied for a period of 48 h following treatment. Penetration showed biphasic kinetics, with a rapid increase of the internal gamma‐HCH concentration during the first 6 h after the application, followed by a plateau up to 48 h. The rate of metabolic degradation was highest between 6 and 24 h. During this period, the rapid decrease in the amount of gamma‐HCH in the larvae was associated with an accelerated excretion of metabolites. A compartmental model with curve‐fitting was used to quantify the rates of uptake through the cuticle (penetration) and of loss from the tissues (degradation and elimination). Chromatographic analysis of the aqueous and organic fractions extracted from the larvae and their faeces provided direct evidence that our susceptible strain ofS. littoraliswas able to metabolise a nonlethal do
展开▼
机译:摘要 以埃及棉叶虫草地贪夜蛾(Boisd.)的易感菌株为研究对象,研究了γ-六氯环己烷(六氯环己烷)的命运。对四龄幼虫局部施用非致死剂量(0·2μg幼虫−1),并在治疗后48 h研究杀虫剂的药代动力学。渗透显示出双相动力学,在施用后的前6小时内,内部γ-六氯环己烷浓度迅速增加,随后在48小时内达到稳定期。代谢降解速率在6-24小时之间最高。在此期间,幼虫中γ-六氯环己烷含量的迅速减少与代谢物的加速排泄有关。使用具有曲线拟合的房室模型来量化通过角质层的吸收率(渗透)和组织损失率(降解和消除)。从幼虫及其粪便中提取的水性和有机馏分的色谱分析提供了直接证据,证明我们的易感菌株 S.littoralis能够代谢非致命的 do
展开▼