Decrease in adherence of bacteria and yeasts to human mucosal epithelial cells by noxythiolinin vitro

摘要

Adherence of buccal and vaginal isolates ofCandida albicansto buccal epithelial cells and the adherence of urine isolates ofEscherichia coliandStaphylococcus saprophyticusto uroepithelial cells was quantified by light microscopy. The antimicrobial agent noxythiolin reduced the adherence of these micro‐organisms in both exponential and stationary growth phases. Adherence of both the blastospore and pseudohyphal forms ofC. albicanswas reduced. Treatment of epithelial cells and/or micro‐organisms with noxythiolin resulted in decreased adherence. No anti‐adherence effect was observed with formaldehyde and N‐methylthiourea, the degradative products of noxy