Mitochondrial DNA sequences are frequently transferred to the nucleus giving rise to the so-called nuclear mitochondrial DNA (NUMT). Analysis of 13 eukaryotic species with sequenced mitochondrial and nuclear genomes reveals a large interspecific variation of NUMT number and size. Copy number ranges from none or few copies in Anopheles, Caenorhabditis, Plasmodium, Drosophila, and Fugu to more than 500 in human, rice, and Arabidopsis. The average size is between 62 (baker's yeast) and 647 bps (Neurospora), respectively. A correlation between the abundance of NUMTs and the size of the nuclear or the mitochondrial genomes, or of the nuclear gene density, is not evident. Other factors, such as the number and/or stability of mitochondria in the germline, or species-specific mechanisms controlling accumulation/loss of nuclear DNA, might be responsible for the interspecific diversity in NUMT accumulation.
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机译：线粒体 DNA 序列经常转移到细胞核，从而产生所谓的核线粒体 DNA （NUMT）。对具有线粒体和核基因组测序的 13 种真核生物物种的分析揭示了 NUMT 数量和大小的种间差异很大。拷贝数范围从按蚊、Caenorhabditis、疟原虫、果蝇和河豚的无拷贝或很少拷贝到人类、水稻和拟南芥的 500 多个拷贝数。平均大小分别在 62（面包酵母）和 647 bps（神经孢子菌）之间。NUMT的丰度与细胞核或线粒体基因组的大小或核基因密度之间的相关性并不明显。其他因素，例如种系中线粒体的数量和/或稳定性，或控制核DNA积累/丢失的物种特异性机制，可能是NUMT积累的种间多样性的原因。
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