The aim of the present study was to evaluate the role played by age at diagnosis of celiac disease (CD), dietary management and menarcheal familiar antecedents in conditioning menarcheal age (MA) in CD. This study covers a population of 94 menarcheal adolescents with untreated CD, whose MA was compared with that of 3 control populations: the 1st consisting of 117 early-treated and compliant CD girls, the 2nd represented by their non-celiac mothers, and the 3rd consisting of 280 healthy adolescents. Average MA of the girls with post-menarcheal diagnosis of CD was superimposable to that of the patients with pre-menarcheal diagnosis and was no different from the one of their mothers or that of healthy controls. The prevalence of delayed menarche was similar in the patients with either pre-menarcheal or post-menarcheal diagnosis of CD. A direct correlation between patients' MA and that of their mothers was detected in both groups of CD patients. We conclude that: a) untreated CD may not be associated with menarcheal retardation; b) MA in CD is significantly affected by maternal MA and may be irrespective of age at diagnosis and dietary management.
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机译：本研究的目的是评估年龄在乳糜泻 （CD） 诊断时、饮食管理和月经熟悉的前因在调节 CD 月经年龄 （MA） 中的作用。本研究覆盖了 94 名未经治疗的 CD 的月经初潮青少年，其 MA 与 3 个对照人群进行了比较：第一个由 117 名早期治疗和依从的 CD 女孩组成，第二个由她们的非乳糜泻母亲代表，第三个由 280 名健康青少年组成。月经后诊断为克罗恩病的女孩的平均MA与月经前诊断为CD的女孩的平均MA可叠加，并且与她们的母亲或健康对照组没有差异。月经初潮延迟的患病率在月经前或月经后诊断为 CD 的患者中相似。在两组 CD 患者中检测到患者的 MA 与其母亲的 MA 之间存在直接相关性。我们得出的结论是：a）未经治疗的克罗恩病可能与月经迟缓无关;b） 克罗恩病中的 MA 受母体 MA 的显着影响，并且可能与诊断和饮食管理时的年龄无关。
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