Microwave-Accelerated Cross-Dehydrogenative Coupling of Quinoxalin-2(1H)-ones with Alkanes under Transition-Metal-Free Conditions

摘要

With simple alkanes as the alkyl radical precursors under microwave irradiation, a convenient and efficient cross-dehydrogenative alkylation reaction of quinoxalin-2(1H)-ones and other N-heteroarenes has been achieved. The protocol demonstrates a broad substrate scope, good functional group tolerance, high atom economy and high efficiency, providing a wide range of valuable, structurally diverse C3 alkylated quinoxalin-2(1H)-ones and other alkylated N-heteroarenes in good-to-excellent yields.