High-sensitivity cardiac troponin (hs-cTn) testing has enabled shorter time intervals between serial measurements when assessing patients with possible acute coronary syndrome (ACS) with the use of a single sample strategy proposed for early risk stratification. Specifically, a rapid rule-out for myocardial infarction (MI) is suitable for a pathway if the sensitivity for 30-day cardiac events is ≥ 99. At the population level (n = 131,095 emergency department ED patients), low hs-cTn results alone yielded sensitivities 99.0 in patients ≥ 65 years of age.
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