The Role of Polymorphic Markersrs1478604,rs2292305, andrs2228262inTHBS1Gene in the Development of Autoimmune Dry Eye Syndrome

摘要

An association of polymorphic markerrs2228262in theTHBS1gene with the risk of developing dry eye in Sjogren syndrome was revealed. Confocal microscopy data suggest that this polymorphic marker is responsible for the high probability of corneal nerve fiber lesion in Sjogren syndrome even in the absence of clinical and functional signs of dry eye syndrome. A significant correlation was established between polymorphic markersrs1478604,rs2228262inTHBS1gene and the coefficients of anisotropy and orientation symmetry of corneal nerve fibers. These results allow considering these polymorphic markers as a genetic factor of predisposition to dry eye syndrome in patients with Sjogren syndrome.