Isolation and Characterization of Anti-Inflammatory Chromones from Imperata cylindrica var. major

摘要

One new chromone, 5-hydroxy-8-O-β-D-glucopyranosyl-2-(2-phenylethyl)chromone (1), along with 13 known ones (2–14) were obtained and identified from a 70 EtOH extract of Imperata cylindrica var. major (Nees) C. E. Hubb. rhizomes. Among the known isolates, 3, 6, 10, 11, 13, and 14 were gained firstly from the Imperata genus. The lipopolysaccharides (LPS)-induced RAW 264.7 cell model was established to evaluate the potential anti-inflammatory activities of all compounds. As a result, potential anti-inflammatory activity of 2, 3, 7, and 8 was concentration dependent with the best effect at 3, 10, and 30 μM.