Purpose: To assess the efficacy of 0.01 atropine eye drops in decreasing the progression of myopia in Indian children. Methods: We conducted a prospective interventional study. Subjects with a baseline myopia of >-2.0D to -6D were randomised into two groups, Group A received 0.01 atropine eye drops and Group B received artificial tear drops every night for a period of one year. Spherical equivalent (SE) and axial length (AL) were measured to assess progression. Minimum follow up was one year. Results: A total of 60 eyes were included. Mean age was: Group A (n = 30): 11.33 ± 3.31 years and Group B (n = 30): 10.8 ± 3.41 years (p = 0.602). Mean pre inter-ventional SE was Group A: -3.65 ± 1.08D; Group B: -3.8 ± 1.15D (p = 0.603). Mean pre interventional AL was Group A: 24.05 ± 1.27 mm; Group B: 24.62 ± 0.9 mm(p = 0.068). The progression of SE in two groups was: Group A: -0.53 ± 0.16D; Group B: -1.01 ± 0.50D (p = 0.01); and the progression of AL in two groups was: Group A: 0.16 ± 0.03 mm; Group B: 0.31 ± 0.01 mm (p = 0.008). Conclusion: 0.01 atropine eye drops are a safe and effective treatment modality in reducing myopia progression (in terms of both spherical equivalent as well as axial length) in Indian children.
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