Back pain (BP) is one of the most common problems seen by general practitioners. The aim of this pilot registry study was to evaluate the effects of Pycnogenol~(?)(French Maritime Pine Bark extract) on pain, mobility and muscle spasm in patients with recurring episodes of back pain without any other clinical condition. The registry follow-up lasted 3 weeks. Subjects used either SM (standard management), including mild exercise and 3 days of resting or immobilization - or SM+Pycnogenol~(?)200 mg/day (4 cps/day). Eighty-two subjects were included in the study, 23 took Pycnogenol~(?)and 59 were in the SM group. No safety problems or tolerability problems were observed with Pycnogenol~(?)or with the SM. The two groups, SM and SM+Pycnogenol~(?), were comparable at inclusion. A prevalent localization to the lower part of the back/spine was observed in all patients of both groups. The improvement in Karnofsky performance status Scale - expressing the global physical capacity of the individuals - during the 3 weeks of follow-up was significantly higher and faster in the Pycnogenol~(?)group (P<0.05) compared to SM. Patients were able to restart physical training in 3 weeks with Pycnogenol~(?)(in comparison with 4.5 weeks with SM only). The decrease in back pain score (VASL score) was faster and more pronounced with Pycnogenol~(?)(P<0.05) compared to SM. Oxidative stress was significantly reduced in subjects using Pycnogenol~(?)(P<0.05) while it remained elevated in the control group. The use of the rescue medication doses (ibuprofen) was significantly higher in the SM only (P<0.05) in comparison with SM+Pycnogenol~(?). Pycnogenol~(?)appears to be an effective and safe supplementary management in healthy subjects with idiopathic BP. Mobility, pain, general physical capacity and oxidative stress improved in only a week with further improvements up to 4 weeks in most patients; results appear to be better and faster with Pycnogenol~(?)supplementation than with SM alone.
展开▼
