Dear Editor,We read with great interest the recent article “COV-ID-19 Infection in a Patient with End-Stage Kidney Disease” by Fu et al. 1. Previous studies have reported that ~ 10 of infected patients may develop acute kidney injury (AKI), which is a strong prognostic factor increasing risk of death 2-4. We agree with the authors that SARS-CoV2 affects the kidney function and special care of renal function should be taken into account in COVID-19 patients. However, the current definition of AKI does not provide a measurement of loss of kidney function because serum creatinine level is not a sensitive marker of early tubular injury (elevation of serum creatinine requires damage/dysfunction of >50 of the nephron mass), whereas biomarkers of tubular injury provide information on early kidney injury and response to noxious stimuli 5.
展开▼
