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Hypopharyngeal Reconstruction: Possibilities, Outcomes, and Updates for Improving the Human Health for Quality of Life

机译:下咽重建:改善人类健康以提高生活质量的可能性、结果和更新

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摘要

Hypopharyngeal carcinoma is usually present at late stages, necessitating an aggressive line of management consisting of surgical procedures, chemotherapy, and radiation therapy, depending on the case. Practitioners tend to support total laryngectomies or total esophagostomies for most cases of hypopharyngeal carcinoma. The extensive procedures needed will most probably require, depending on the residual defect, a follow-up reconstructive procedure that might require utilizing flaps. Types of reconstructive methods and types of grafts or flaps used could be divided into a multitude of categories depending on the magnitude, shape, extension, and whether the underlying defect that is being reconstructed is circumferential or not. These reconstructive procedures are aimed at improving the quality of life, improving the aesthetic outcome, and restoring the functionality of the pharyngoesophageal segment. When it comes to hypopharyngeal cancer, the most common kind is squamous cell carcinoma (SCC), which has the worst prognosis of all the head and neck malignancies. Overall, the 5-year survival rate remains low, despite recent advancements in diagnostic imaging, radiation, and chemotherapy, as well as enhanced surgical methods and techniques. Hypopharyngeal malignancies are more probable than other tumors to present with advanced primary illness, with nodal metastasis a distinct possibility. The size and amount of local dissemination of the original carcinoma, as well as the extent of involvement of regional lymph nodes, are the most critical factors in predicting prognosis. Hypopharyngeal cancers are more likely than other head and neck cancers to manifest with distant metastases at the time of diagnosis. The appearance of second primary tumors, as well as the development of distant metastases, is a contributing factor to poor survival rate. Imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) with contrast remain the gold standard for evaluating hypopharyngeal carcinoma in the early stages. In most cases, imaging leads to an increase in the tumor stage at the time of presentation. Objectives. The main objectives are to review the research published about flaps, outline the optimum situations that will dictate the usage of a few of the most often used flaps for the rebuilding of the hypopharyngeal segment defects, and outline some of the complications associated with reconstruction. Methods. The processing was carried out with the title-specific search of the PubMed database using the query terms “hypopharyngeal carcinoma” and “reconstruction” to identify the most relevant articles without restricting publication dates. Information about the types of defects and methods of reconstruction was extracted from the reviewed articles. Two books were also reviewed, which were Regional and Free Flaps for Head and Neck Reconstruction (second edition) and Head and Neck Reconstruction: A Defect-Oriented Approach. Conclusion. Deciding the appropriate approach to a case should be individualized and should depend on the capabilities of the center, the defect’s size and status, and lastly, the surgeon’s training. The use of interpretation in the diagnosis of flaps can offer the best results in restoring functionality and vascularity and might also offer improved cosmesis.
机译:下咽癌通常出现在晚期,需要根据具体情况采取积极的治疗措施,包括外科手术、化疗和放疗。对于大多数下咽癌病例,从业者倾向于支持全喉切除术或全食管切开术。根据残余缺损,所需的大量手术很可能需要后续的重建手术,可能需要使用皮瓣。重建方法的类型和使用的移植物或皮瓣的类型可以分为多种类别,具体取决于大小、形状、延伸以及正在重建的潜在缺陷是否是圆周的。这些重建手术旨在改善生活质量,改善美学效果,并恢复咽食管段的功能。说到下咽癌,最常见的是鳞状细胞癌(SCC),它是所有头颈部恶性肿瘤中预后最差的。总体而言,尽管最近在诊断成像、放疗和化疗方面取得了进展,以及增强的手术方法和技术,但 5 年生存率仍然很低。与其他肿瘤相比,下咽恶性肿瘤更可能表现为晚期原发性疾病,淋巴结转移的可能性很大。原发癌局部播散的大小和数量,以及区域淋巴结的受累程度,是预测预后最关键的因素。与其他头颈癌相比,下咽癌在诊断时更有可能表现为远处转移。第二原发性肿瘤的出现以及远处转移的发展是导致生存率低的一个因素。成像技术,如计算机断层扫描 (CT) 和增强磁共振成像 (MRI) 仍然是早期评估下咽癌的金标准。在大多数情况下,影像学检查会导致就诊时肿瘤分期的增加。目标。主要目的是回顾已发表的关于皮瓣的研究,概述决定使用一些最常用的皮瓣重建下咽段缺损的最佳情况,并概述与重建相关的一些并发症。方法。使用查询词“下咽癌”和“重建”对 PubMed 数据库进行特定于标题的搜索,以在不限制出版日期的情况下识别最相关的文章。从综述的文章中提取了有关缺陷类型和重建方法的信息。还审查了两本书,分别是《头颈部重建的区域和游离皮瓣》(第二版)和《头颈部重建:以缺陷为导向的方法》。结论。决定对病例的适当方法应该是个体化的,应该取决于中心的能力、缺陷的大小和状态,最后是外科医生的培训。在皮瓣诊断中使用解释可以在恢复功能和血管方面提供最佳效果,并且还可以改善美容效果。

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