首页> 外文期刊>Bulletin of experimental biology and medicine >Nootropic Activity of Prospekta in a Blind Placebo-Controlled Study in a Model of Focal Cerebral Ischemia in Rats
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Nootropic Activity of Prospekta in a Blind Placebo-Controlled Study in a Model of Focal Cerebral Ischemia in Rats

机译:Prospekta在大鼠局灶性脑缺血模型中的盲法安慰剂对照研究中的益智活性

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摘要

Analysis of the pharmacological activity of the original drug Prospekta in a rat model of focal cerebral ischemia revealed its nootropic effect: course treatment in the post-ischemic period led to recovery of the neurological status of animals at the peak of neurological deficit. Evaluation of the therapeutic potential of the drug in morphological and functional CNS disorders allowed us to conclude that it is advisable to carry out further studies of its biological activity at the preclinical stage (the results obtained in animals were successfully confirmed in a clinical trial of drug efficacy in the treatment of moderate cognitive disorders in the early recovery period after ischemic stroke). Studies of the nootropic activity in other pathologies of the nervous system are also promising.
机译:对局灶性脑缺血大鼠模型中原始药物Prospekta的药理活性的分析揭示了其促智作用:缺血后期的疗程治疗导致动物在神经功能缺损高峰期的神经状态恢复。评估药物在形态学和功能性中枢神经系统疾病中的治疗潜力使我们能够得出结论,建议在临床前阶段对其生物活性进行进一步研究(在缺血性中风后早期恢复期治疗中度认知障碍的药物疗效的临床试验中成功证实了在动物中获得的结果)。对神经系统其他病理学中的益智活性的研究也很有希望。

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