Abstract Calcium alginate hollow fibers have been used as bionic vascular channels in thick tissue and organ regeneration studies, whose permeability determines the transport efficiency of nutrients and oxygen. CaCl2 was dissolved in the solvent mixed with isopropyl alcohol (IPA) and deionized water to obtain a series of crosslinking agents with different polarities. Calcium alginate hollow fibers were fabricated by the coaxial flow, and the influence of interfacial polarity on its permeability was studied. The polarity evaluation results showed that the polarity index of the crosslinking agents decreased from 9.00 to 3.90 with the increase in IPA mass concentration. Scanning electron microscopy observations indicated that with the weakening of the interfacial polarity of the coaxial flow, the gel units tended to be shorter and denser along the flow direction. It was worth noting that the permeability did not change synchronously with the polarity, but first enhanced and then weakened with the decrease in the polarity. When the mass concentration of IPA exceeded 60, the regulation ability of interfacial polarity on permeability was significantly improved. The research results will have a positive effect on the customization of physicochemical properties of alginate.Graphical abstract
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