A novel Iron(III)-based MOF: Synthesis, characterization, biological, and antimicrobial activity study

摘要

Recently infectious diseases and increasing microbial drug-resistant have caused many humorless health problems. To fill knowledge gaps and guide strategies at all levels for antimicrobials which represent a challenge and an urgent need. For these reasons, our target is developing a new effective antimicrobial drug with extended action time, multi-antimicrobial agents, low toxicity, and safe strategies. Metal-organic frameworks are promising materials for antimicrobial agents. Herein, a novel affordable Fe(III)-MOF was simply prepared via a reflux method. FE-SEM images showed an octahedral structure with sharp edges with high crystallinity and purity of Fe(III)-MOF. Under optimum conditions, the Fe(III)-MOF showed excellent antimicrobial efficiency against +/- bacteria, fungus, and yeast with an inhibition zone ranging between 40-46 and 22-24 mm at a concentration of 50 and 25 mu g/mL Fe(III)-MOF, respectively. As well, the mechanism of interaction is also well studied.The results open the door for the use of prepared materials as an effective and efficient antimicrobial agent.