Should we use weight-based vitamin D treatment in children?

摘要

Vitamin D deficiency (VDD) is a perennial problem in the UK.The Royal Osteoporosis Society (ROS) guideline for treatment of VDD, defined as 25-hydroxyvitamin D (25-OHD) 12 years: 10 000 lU/d for 8-12 weeks ? alternative >12 years: 300 000 lU/day total in single or divided dose This is supported by the British Society of Paediatric Endocrinology and Diabetes and the RCPCH vitamin D resource page. We planned to determine whether treatment resulted in an increase in serum 25-OHD to over 50 nmol/L and how this related to dose/kg.