DETERMINATION OF SOME SELECTEDPHARMACEUTICALS IN MARINE BIOTA:A CASE STUDY IN THE ISTANBUL METROPOLITAN AREA,TURKEY

摘要

This paper presents data on eleven pharmaceu-ticals of different classes(nonsteroidal anti-inflam-matory drugs, blood lipid regulators, antiepileptics and hormones)in biota(mussels, macroalgae, fish muscle tissue) from the Golden Horn Estuary, Tur-key. An ultrasonicextraction method was used to ex-tract pharmaceuticals from the biota. The solid-phase extraction(SPE)method was used for clean-up. High-performance liquid chromatography (HPLC) with a DAD detector was used to quantify the pharmaceuticals. All target compounds were de-tected in at least one of the samples. Gemfibrozil (56-9135 ng/g) was the most frequently detected compound in all biota samples. Five pharmaceuticals were detected in the macroalgae samples at a maxi-mum concentration of 7221 ng/g for gemfibrozil. Additionally, nine of the pharmaceutical compounds were detected in several or all of the seven fish spe-cies. The highest concentration of 17α-ethinylestra-diol detected in Mullus barbatus was 1258 ng/g. The concentrations of diclofenac (4694 ng/g), naproxen (1570 ng/g), ibuprofen(5098 ng/g),17β-estradiol (2364 ng/g),clofibric acid(1296ng/g),and gemfib-rozil(9135 ng/g) were considerably higher in mus-sels than in other biota species. The accumulation potential of pharmaceutical compounds was higher in mussels than in other biota species.