Copper-Catalyzed 2+2+1+1 Annulation for the Regioselective Synthesis of 2,6-Diarylpyridines via C1-Insertion and Subsequent Cyclization

摘要

Copper-catalyzed 2+2+1+1 annulation strategy has been investigated for the regioselective synthesis of symmetrical and unsymmetrical 2,6-diarylpyridines using aliphatic amines as nitrogen source and DMSO as C1-synthon. The developed protocol was successful for the transformation of non-activated aromatic ketones and non-activated aliphatic amines into 2,6-diarylpyridinesviaan "easy to access" approach. This protocol has been verified on wide range of substrates having various functional groups.