Re: Sancer et al. (2020) “Comparison of DNA damage and proliferative capacities in smear samples of HPV positive and negative patients by micronucleus counting and AgNOR staining,” Biotechnic histochemistry, https:// doi.org/10.1080/10520295.2020.1800091) Dear Editor: An article by Sancer et al. (2020), “Comparison of DNA damage and proliferative capacities in smear samples of HPV positive and negative patients by micronucleus counting and AgNOR staining,” Biotechnic histochemistry, https://doi.org/10.1080/ 10520295.2020.1800091) published in your journal presents interesting data concerning micronuclei (MN) rates in cervical cells of HIV-positive patients. Recently, a meta-analysis (Setayesh et al. 2020) was published concerning MN in cervical cells for predicting and detecting cervical cancer in which the rates of MN in cancer patients and infected with HPV individuals were reported. The rates of MN reported in the analyzed studies are drastically different from the data presented by Sancer et al. (2020). Sancer et al. (2020) reported that “MN frequency was 8.2 on HPV negative slides, 19.2 on HPV 16/18 slides and 9.6 on HR positive slides.” Such extremely high rates of MN in cervical cells are not possible. In fact, this parameter in healthy women, based on the results presented in papers cited by the authors, has been reported to be 0.0003 (Adam et al. 2015), 1.2 (Ambroise et al. 2013), and 5.14 (Cortes-Gutierrez et al. 2005), respectively, i.e., several times less than reported by the authors.
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