Respiratory prehabilitation in pediatric anesthesia in children with muscular and neurologic disease

摘要

Abstract Children with neuromuscular, chronic neurologic, and chest wall diseases are at increased risk of postoperative respiratory complications including atelectasis, pneumonia, and respiratory failure with the possible need for reintubation or even tracheostomy. These complications negatively impact patient outcomes, including increased healthcare resource utilization and increased surgical mortality. In these children, the existing respiratory reserve is often inadequate to withstand the stresses brought on during anesthesia and surgery. A thorough clinical assessment and objective evaluation of pulmonary function and gas exchange can help identify which children are at particular risk for poor postoperative outcomes and thus merit preoperative interventions. These may include initiation and optimization of non‐invasive ventilation and mechanical insufflation‐exsufflation. Furthermore, such an evaluation will help identify children who may require a postoperative extubation plan tailored to neuromuscular diseases. Such strategies may include avoidance of pre‐extubation lung decruitment by precluding continuous positive airway pressure trials, aggressively weaning to room air and directly extubating to non‐invasive ventilation with a high inspiratory to expiratory pressure differential of at least 10?cm H20. Children with cerebral palsy and other neurodegenerative or neurodevelopmental disorders are a more heterogeneous group of children who may share some operative risk factors with children with neuromuscular disease; they may also be at risk of sleep‐disordered breathing, may also require non‐invasive ventilation or mechanical insufflation‐exsufflation, and may have associated chronic lung disease from aspirations that may require perioperative treatment.