Abstract A regioselective and nucleophilic halogenation of electron‐rich amidophenols was realized in the presence of Fe(III) reagents and amido‐directing groups. Halides could be sequentially introduced to specific positions to form mono‐, di‐ and mixed di‐ halogenated amidophenols. Furthermore, this protocol provides new methods for the syntheses of IKK2 inhibitor (IMD‐0354), muscle relaxant (Chlorzoxazone) and related derivatives.
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