Aging behavior of Y-TZP with bioglass addition and its impact on the flexural strength and osteoblastic cell response

摘要

Y-TZP containing Ca(2)P(2)O(7)are promising bioceramics with potential applications in dental implants and dentistry. These ceramics were developed by the introduction of a refractory sol-gel derived CaO-P2O5-SiO(2)bioglass into Y-TZP; Ca2P2O7, and ZrSiO(4)phases were formed in situ after sintering. The aging process of Y-TZP with different glass additions was studied. The effect of glass addition on the flexural strength and osteoblastic cell response of non-aged and aged Y-TZP was investigated. Y-TZP exhibited the most pronounced tetragonal (t) to monoclinic (m) transformation of zirconia (ZrO2) during aging; the addition of glass contents between 5 and 20 vol improved the aging resistant of Y-TZP. Y-TZP flexural strength markedly decreased with increasing aging time; in contrast, the ceramics with glass did not alter their flexural strength upon aging. An increase in the Ca(2)P(2)O(7)content with increasing glass up to 10 vol, promoted both the cell viability and the osteogenic differentiation of UMR-106 cells on non-aged and aged samples. The high micro-roughness of Y-TZP with 20 vol glass after aging, limited the proliferation and the osteogenic potential of the cultures. Y-TZP with 10 vol glass had the best combination of properties in terms of flexural strength and osteoblast cell response.