Somatic Mutations in theBRAF,KRAS,NRAS,EIF1AX, andTERTGenes: Diagnostic Value in Thyroid Neoplasms

摘要

The feasibility of using molecular genetic markers associated with thyroid neoplasms and more aggressive course of the disease is now actively studied. We analyzed the diagnostic value of somatic mutations in the hot spots ofBRAF,KRAS,KRAS,EIF1AX, andTERTgenes in histological material from 153 patients with thyroid gland neoplasms.BRAFmutations (exon 15, codon area 600-601) were found in 54 patients,NRASmutations (exon 3, codon 61) were detected in 12 patients; mutationsKRAS,TERT, andEIF1AXgenes were not detected.