Restriction d'hétérogénéité des gammaglobulines sur l'électrophorèse des protéines sériques

摘要

Electrophoresis allows the separation of serum proteins into different fractions in order to study their variations and to interpret them. The gamma globulin zone, in which a large proportion of immunoglobulins (Ig) migrate, gives a picture of the immune response. The normal pattern of this zone is a Gaussian distribution of immunoglobulins, corresponding to a polyclonal synthesis of Ig. Other aspects can be observed, restriction of heterogeneity, oligoclonality and monoclonality. Heterogeneity restriction is the most difficult aspect to interpret, should Ig be identified? Is it necessary to check this aspect regularly? It appears that in some cases it is essential to discuss the clinical context with the physician. This article addresses the problem of defining and perceiving the aspects of heterogeneity restriction and their interpretation, illustrated by examples of concrete clinical contexts.