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Pharmacodynamics of D-mannose in the prevention of recurrent urinary infections

机译:D-甘露糖预防复发性尿路感染的药效学

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Recurring urinary tract infections (rUTIs) are frequently caused by Escherichia coli, which invades urothelial cells and forms quiescent bacterial reservoirs. D-mannose, an inert monosaccharide, represents a notable agent for rUTI prevention; however, there is no agreement on its dosage. To provide pharmacological basis for an effective dose, we evaluated its ability to inhibit adhesion of E. coli to urothelial cells. E. coli strains isolated from the urine of a woman with recurrent urinary tract infections were selected according to adhesion capacity. Anti-adhesive efficacy and invasion were tested using the TCC-5637 urothelial cell line. The 1050 for the anti-adhesive efficacy and anti-invasion activity of D-mannose were 0.51 mg/ml and 0.30 mg/ml, respectively, both with concentration-dependent inhibition. Lastly, the biofilm interference of D-mannose was evaluated to be 50 mg/ml. D-mannose inhibited the adhesion of E. coli to urothelial cells at high concentrations, whereas inhibition of invasion occurred at much lower concentrations.
机译:复发性尿路感染 (rUTI) 通常由大肠杆菌引起,大肠杆菌侵入尿路上皮细胞并形成静止的细菌库。D-甘露糖是一种惰性单糖,是预防 rUTI 的重要药物;但是,对其剂量没有达成一致。为了提供有效剂量的药理学依据,我们评估了其抑制大肠杆菌与尿路上皮细胞粘附的能力。根据粘附能力选择从复发性尿路感染妇女的尿液中分离出的大肠杆菌菌株。使用 TCC-5637 尿路上皮细胞系测试抗粘附功效和侵袭。D-甘露糖的抗粘附功效和抗侵袭活性分别为0.51 mg/ml和0.30 mg/ml,均具有浓度依赖性抑制作用。最后,D-甘露糖的生物膜干扰为50 mg/ml。D-甘露糖在高浓度下抑制大肠杆菌与尿路上皮细胞的粘附,而在低得多的浓度下抑制侵袭。

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