Venous gangrene is a rare condition, which indicates soft tissue necrosis in a limb with deep venous thrombosis and usually occurs in patients with a prothombotic condition. Malignancy is a strong risk factor for deep venous thrombosis, but without its associated disseminated intravascular coagulation, is a rare cause of venous gangrene. Anticoagulation remains an effective treatment for these patients. Unfortunately, if the treatment delays or the arterial hypoperfusion is established, amputation may be considered a palliative way of treatment. We present an interested and rare case of venous gangrene, in a patient with multiple myeloma.
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