Multivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries

摘要

Abstract The minor allele of rs373863828, a missense variant in CREB3 Regulatory Factor, is associated with several cardiometabolic phenotypes in Polynesian peoples. To better understand the variant, we tested the association of rs373863828 with a panel of correlated phenotypes (body mass index BMI, weight, height, HDL cholesterol, triglycerides, and total cholesterol) using multivariate Bayesian association and network analyses in a Samoa cohort (n?=?1632), Aotearoa New Zealand cohort (n?=?1419), and combined cohort (n?=?2976). An expanded set of phenotypes (adding estimated fat and fat‐free mass, abdominal circumference, hip circumference, and abdominal‐hip ratio) was tested in the Samoa cohort (n?=?1496). In the Samoa cohort, we observed significant associations (log10 Bayes Factor BF?≥?5.0) between rs373863828 and the overall phenotype panel (8.81), weight (8.30), and BMI (6.42). In the Aotearoa New Zealand cohort, we observed suggestive associations (1.5?