Current and Emerging Pharmacological Targets and Treatments of Urinary Incontinence and Related Disorders

摘要

Overactive bladder syndrome with and without urinary incontinence and related conditions, signs, and disorders such as detrusor overactivity, neurogenic lower urinary tract dysfunction, underactive bladder, stress urinary incontinence, and nocturia are common in the general population and have a major impact on the quality of life of the affected patients and their partners. Based on the deliberations of the sub-committee on pharmacological treatments of the 7th International Consultation on Incontinence, we present a comprehensive review of established drug targets in the treatment of overactive bladder syndrome and the aforementioned related conditions and the approved drugs used in its treatment. Investigational drug targets and compounds are also reviewed. We conclude that, de-spite a range of available medical treatment options, a considerable medical need continues to exist. This is largely because the existing treatments are symptom-atic and have limited efficacy and/or tolerability, which leads to poor long-term adherence.