Purpose: To perform a scoping review on the available literature regarding the side effects of sodium lauryl sulfate (SLS) used in toothpastes. Methods: A scoping review was performed according to the PRISMA extension using PubMed. The electronic search was supplemented with a manual search for a complete overview. A customized data collection form was used to map data which was developed to register the extracted relevant data. The results of the selected articles were classified according to effects in the mouth, on the mucous membrane or elsewhere in the body and the healing effects of SLS-free toothpaste on aphthous ulcers. The outcomes from each category were reported in separate data forms and the studies with incomplete information were excluded from the assessment. Results: Possible harmful effects of SLS were reported as mucosal desquamation, irritation or inflammation of oral mucosa or the dorsal part of the tongue, ulcerations, and toxic reactions in the oral cavity.
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