Why mucosal vaccines could be vital to getting ahead of SARS-CoV-2

摘要

For more than 40 years, Michael Russell, a professor emeritus of microbiology and immunology at the University at Buffalo, New York, has studied the web of specialised cells and secretions that protect the body's mucosal surfaces, including the upper respiratory tract. Yet, despite reams of evidence showing how important the mucosal immune system is, it has remained in the shadow of the more familiar systemic immune system - the bloodborne immune cells and antibodies that fight established infections1.