Functional hydrogels have attracted tremendous interest in biomedical fields. In this study, we prepare hydrogel based on 2-(methacryloyloxy)ethyldimethyl-(3-sulfopropyl) (SBMA) and 2-hydroxyethyl methacrylate (HEMA), and GelMA acts as crosslinking agent to crosslink the P(SBMA-co-HEMA) molecular chain. The hydrogel exhibits excellent mechanical properties (strength up to 1.21 MPa), fatigue resistance (withstands 50 compression tensile cycles and remains stable), and high transmittance enables visualization of hydrogel dressings. Furthermore, antibacterial experiments proves that hydrogel could significantly resist the adhesion of E. coli. and the hydrogel also has excellent antifreezing and water retention properties. More importantly, in vitro and in vivo assays reveals the hydrogel has excellent biocompatibility and stability, making them competitive candidates for biomedical applications such as wound dressing.
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