Endotoxins modify muscle fatigue characteristics

摘要

Summary—To test the hypothesis that endotoxins can directly modify muscle fatigue characteristics,in vitroexperiments were performed on rat muscles 48 hours after injection of lipopolysaccharides (LPS) fromKlebsiella pneumoniae.Resistance to fatigue was quantified by measuring tension production during repetitive electrical stimulation of the isolated epitrochlearis muscle. LPS treatment did not significantly modify initial force production whereas fatigability of the muscle was increased. Thisin vitropreparation should be used for testing antifatigue drug