Synthesis, Photooxygenation and DNA Studies of Novel Fused Furo, Dioxolo, and Dioxino Derivatives of Coumarin

摘要

abstract_textpSyntheses of novel fused furo, dioxolo and dioxino derivatives of coumarin are carried out through the reaction of 7,8-dihydroxycoumarin derivative1with alpha-halocarbonyl compounds (alpha-haloketone, alpha-haloester and chloroacetyl chloride) and 1,2-dichloroethane. The photooxygenation of synthesized furocoumarin derivative was performed and the affinity of furocoumarin derivative towards DNA was evaluated and compared with 8-methoxypsoralen (8-MOP), which extensively used in photochemotherapy./p/abstract_text