Live Delivery in a 46.5-Year-Old Woman in Overt Menopause by Restoring Follicular Sensitivity to Follicle Stimulating Hormone (FSH)

摘要

For almost 40 years, there have been several publications where ovulation induction has occurred by lowering elevated serum follicle stimulating hormone (FSH) to up-regulate down-regulated FSH receptors on granulosatheca cells thus restoring follicular sensitivity to endogenous gonadotropin resulting in live deliveries. The majority of case reports used ethinyl estradiol to lower FSH. The advantage of ethinyl estradiol is that it does not add to the serum estradiol and thus allows the physician to better determine follicular maturation. To date the oldest woman to have ovulation induction and live delivery despite menopause was aged 45. A 46.