Application of low-dose etomidate combined with oxycodone and midazolam in endoscopic injection sclerotherapy

摘要

Objective: To evaluate the ad-verse effects and particularly the anesthetic effect of low-dose etomidate combined with oxycodone and midazolam in endoscopic injection sclerotherapy. Materials and meth-ods: We herein report a prospective, double-blind, randomized controlled trial. It includ-ed patients with liver cirrhosis (age, 18 - 65 years; BMI, 18 - 25 kg/m2) who were treated with endoscopic injection sclerotherapy, and the patients were randomly assigned to the propofol group or the etomidate group. The incidence of respiratory depression was the primary outcome measure. The occurrence of various adverse effects and endoscopist satisfaction score were the secondary out-come measures. Results: In this study, we enrolled a total of 96 patients. The incidence of respiratory depression in the propofol group was 19, while that in the etomi-date group was only 4 (9/47 vs. 2/49; p = 0.026). Regarding the secondary outcome measures, the incidence of hypoxia in the propofol group was 15, while that in the etomidate group was only 2 (7/47 vs. 1/49; p = 0.029). Injection-site pain occurred in 0 and 23 of the patients in the etomidate group and propofol group, respectively (p < 0.001). Endoscopist satisfaction scores were classified as "poor", "fair", "good", and "very good". The scores were 17 higher (46/49 vs. 36/47; p = 0.026) for the "very good" lev-el and 15 lower (3/49 vs. 10/47; p = 0.038) for the "good" level in the etomidate group than in the propofol group. Conclusion: Low -dose etomidate combined with oxycodone and midazolam for endoscopic injection sclerotherapy could reduce the incidence of hypoxia without increasing the incidence of complications.