Validation of self‐reported medication use applying untargeted mass spectrometry‐based metabolomics techniques in the Rhineland study

摘要

Aims To assess the validity of self‐reported continuous medication use with drug metabolites measured in plasma by using untargeted mass spectrometric techniques. Methods In a population‐based cohort in Bonn, Germany, we compared interview‐based, self‐reported medication intake with drug‐specific metabolites measured in plasma (based on participants who completed their study visits between March 2016 and February 2020). Analyses were done stratified by sex and age (?0.8), whereas sitagliptin and hydrochlorothiazide showed substantial (κ?=?0.8, 95 CI 0.71–0.90) and moderate agreement (κ?=?0.61, 95 CI 0.56–0.66), respectively. Frequency of use allowed sex‐ and age‐stratified analyses for eight and nine drugs, respectively. For five drugs, concordance tended to be higher for women than for men. For most drugs, concordance was higher among individuals aged ≥65?years than among individuals aged <65?years, but these age‐related differences were not statistically significant. Conclusion High concordance rates between self‐reported drug use and metabolites measured in plasma suggest that self‐reported drug use is reliable and accurate for assessing drug use.